| Abstract |
Objectives:
We invesigated body composition, HOMA-IR, glucose tolerance, and lipid profile before and after an aerobic exercise program in healthy non-diabetic subject with elevated risk of developing diabetes as prevention to type 2 diabetes.
Materials & Methods:
The study was conducted by randomized controlled intervention design to investigate effect of aerobic training among healthy non-diabetic subjects with elevated risk of developing diabetes. People with elevated risk of developing diabetes defined as being first degree relative of diabetes or having central obesity (BMI>= 23,0 and percent body fat>= 25 %) or elevated blood glucose within normal range (fasting blood glucose: 90-99 mg/dl). Participants (N= 26, age : 22-38, 69 % female) participated in a 10-week aerobic exercise program (3 sessions/week, 45 minutes/session). Body composition (measured by bio-impedance analysis using Inbody 720), insulin sensitivity (measured by Homeostatis Model Assessment, HOMA-IR), glucose tolerance using OGTT, and lipid profile were examined at baseline and endpoint of intervention.
Result & Findings:
For 26 subjects were assigned to a 10-week aerobic exercise program. Ten participants completed exercise program. After intervention, only fasting blood glucose was significantly reduced (-5,3 mg/dl, 95 % CI: -9,03 to -1,57, P: 0,011). However, sub-group analysis showed overweight and obese group (n= 8) had significantly reduced fasting blood glucose, fat mass, body mass index (BMI), waist-to-hip ratio (WHR), and estimated visceral fat (P< 0.05). Changes of HOMA-IR, 2-h plasma glucose, fasting insulin, total cholesterol, HDL, LDL, triglycerides, body weight, muscle mass, and percent body fat were not statistically significant.
Conclusion:
A 10-week aerobic exercise program improved fasting blood glucose level. Better body composition changes by aerobic exercise program were more profound in overweight and obese group. These results suggest aerobic exercise is effective to prevent diabetes in healthy non-diabetic subjects with elevated risk of developing diabetes. |